Author(s):
1. Stojko Vidovic, Medicinski fakultet Banja Luka , Republic of Srpska, Bosnia and Herzegovina

Abstract:
Background: Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide. The SIRT1 gene, known for its role in cardiovascular protection and metabolic regulation, may influence susceptibility to AMI. This study investigates the association between the SIRT1 rs7069102 C>G polymorphism and the risk of AMI in a cohort of patients from the Republic of Srpska. Methods: A total of 95 patients with clinically confirmed AMI and 95 healthy controls were genotyped for SIRT1 rs7069102 (C>G). Genotype frequencies were compared between cases and controls. Lipid profiles were analyzed only in the patient group. The dominant model (CG + GG vs. CC) and recessive model (GG vs. CC + CG) were used to assess risk. Odds ratios (OR) with corresponding p-values were calculated. Results: Carriers of at least one G allele (CG or GG) showed an approximately 2.29-fold increased risk of AMI compared to the CC genotype (OR 2.29, p=0.007). In the recessive model, homozygous GG individuals had a 1.73-fold increased risk relative to carriers of at least one C allele, although this difference did not reach statistical significance (OR 1.73, p=0.06). Lipid parameters within the patient group revealed variations that may correlate with genotype, warranting further longitudinal analysis during follow-up for clinical outcomes including echocardiographic changes, ejection fraction, and mortality. Conclusion: The SIRT1 rs7069102 G allele is significantly associated with an increased risk of AMI in this population. These findings highlight the potential role of SIRT1 genetic variants in AMI susceptibility and encourage further investigations into their impact on disease progression and prognosis.

Key words:
"Acute myocardial infarction", "genotype"," SIRT1 gene"

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
21.08.2025.

Conference:
Contemporary Materials 2025 - Savremeni Materijali