Author(s):
1. Ema Begović, Prirodno matematički fakultet Univerziteta u Novom Sadu, Departman za hemiju, biohemiju i zaštitu ži, Serbia
2. Nevena Jokić, Prirodno matematički fakultet Univerziteta u Novom Sadu, Departman za hemiju, biohemiju i zaštitu ži, Serbia
3. Gorana Mrđan, Prirodno-matematički fakultet u Novom Sadu, Serbia
4. Suzana Apostolov, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Serbia
5. Đenđi Vaštag, Serbia
6. Borko Matijević, Serbia

Abstract:
Thiocarbohydrazone derivatives belong to the class of biologically active compounds. Many compounds tested so far have proven to be good antioxidant, antimicrobial, anti-inflammatory, and antitumor agents. Compounds based on thiocarbohydrazide are divided into mono- and bisubstituted derivatives, while bisubstituted derivatives can be symmetrical and asymmetrical. In this paper, the intermolecular interactions of eight newly synthesized asymmetric thiocarbohydrazones in twelve solvents of different properties were investigated using Kamlet-Taft’s solvatochromic model. Also, the influence of the type of the substituent present on shifts in the absorption spectra was examined by applying Hammett's equation. Definition of the type, intensity, and dominance of the interactions that occur between the dissolved substance and the surrounding medium is of great importance when it comes to the physicochemical characterization of newly synthesized derivatives, and can also provide information on the potential biological activity of the tested compounds.

Key words:
Hammett’s equation, intermolecular interactions, Kamlet-Taft’s solvatochromic model, thiocarbohydrazones

Thematic field:
SYMPOSIUM A - Science of matter, condensed matter and physics of solid states

Date of abstract submission:
01.07.2024.

Conference:
Contemporary Materials 2024 - Savremeni Materijali

Applied paper from author Final paper