Author(s):
1. Isidora Milanović, Visoka zdravstvena skola strukovnih studija u Beogradu, Serbia
2. Sasa Vukmirovic, Medicinski fakultet Univerziteta u Novom Sadu, Serbia
3. Nebojša Stilinović, Medicinski fakultet Univerziteta u Novom Sadu, Serbia
4. Momir Mikov, Medicinski fakultet Univerziteta u Novom Sadu, Serbia
5. Aleksandar Rašković, Medicinski fakultet Univerziteta u Novom Sadu, Serbia

Abstract:
Introduction: Rosemary essential oil can be used for treating dyspepsia, mild spasmodic disorders of the gastrointestinal tract, externally as analgetic in muscular and articular pain and minor peripheral circulatory disorders. It is important to explore its analgetic potential and its influence on the pharmacodynamic and pharmacokinetic properties of paracetamol. Methodology: Rosemary essential oil was applied to mice orally (10 and 20 mg/kg b.w.) for seven days and in single dose for the pharmacodynamic tests. Rats treated with rosemary essential oil for seven days orally (5 and 10 mg/kg b.w.) were used for the examination of influence of essential oil on the pharmacokinetic properties of paracetamol (applied on the 7th day p.o. or i.v.). The parameters of pharmacokinetic were analyzed in blood samples obtained from rats tail veins, with the HPLC method. Results: The essential oil of rosemary shows analgetic properties . The rosemary essential oil increases pharmacological effects of paracetamol and does not change paracetamol bioavailability. Conclusion: The herbal drugs could change the pharmacodynamic and the pharmacokinetic properties of clasical drugs and also they could change safety of use clasical drugs in human population.

Key words:
Rosemary,Herb-Drugs Interactions,Paracetamol

Thematic field:
General and Applied Chemistry

Date of abstract submission:
14.09.2016.

Conference:
XI Savjetovanje hemičara, tehnologa i ekologa Republike Srpske

Paper for reviews Final paper